Welcome to BecA bioinformatics page
This portal serves to introduce various bioinformatics resources and tools to aid ABCF placements analyse and intepret their data.
Bioinformatics Modules
Introduction to Bioinformatics
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Linux for biology
This module is designed for scientists hoping to analyze genomic datasets, but who have no experience with the UNIX computing environment or common genomic analysis tools.
Basic sequence analysis
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Pairwise and Multiple sequence alignments
Sequence alignment is a widely used bioinformatic technique to try to align several related sequences to find residues / bases which are conserved between sequences and which are variable. Conserved residues may be an essential part of the active site of an enzyme for example, and variable residues could be part of a 'generic' alpha helix.
Phylogeny and evolutionary relationships
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Population Genetics
Population genetics is the study of the distributions and changes of allele frequencies in a population, as it is subject to four main processes: mutation, selection, genetic drift and genetic recombination.
Advanced: Functional genomics
Presentation from Canadian Bionformatics Wortkshop
Covers: Basics of NGS data analysis- alignments, NGS formats, visualisation and pipelines
Presentation from Canadian Bionformatics Wortkshop
Covers: Expression and Differential Expression- RPKM/FPKM; cuffmerge/ cuffdiff; cummeRbund
Presentation from Canadian Bionformatics Wortkshop
Covers: Isoform discovery and alternative expression: Cufflinks
Presentation from University of Leipzig : Comprehensive NGS analysis
Advanced: Genotyping by Sequencing
Genotyping by sequencing is cost-effective for populations with complex genomes or limited available resources