PROVEAN (Protein Variation Effect Analyzer) is a software tool which predicts whether an amino acid substitution or indel has an impact on the biological function of a protein.

• Latest version: 1.1.5
• Added: March, 2018
• Link: http://provean.jcvi.org/index.php

See versions of provean which are available:

module avail provean

Load one version into your environment and run it:

$ module load provean/1.1.5
$ provean

Notes from the sysadmin during installation:

$ cd /tmp
$ wget https://tenet.dl.sourceforge.net/project/provean/provean-1.1.5.tar.gz
$ tar xf provean-1.1.5.tar.gz
$ cd provean-1.1.5
$ ./configure --prefix=/export/apps/provean/1.1.5 BLAST_DB=/export/data/bio/ncbi/blast/db/nr PSIBLAST=/export/apps/blast/2.7.1+/bin/psiblast BLASTDBCMD=/export/apps/blast/2.7.1+/bin/blastdbcmd CDHIT=/export/apps/cd-hit/4.6.6/cd-hit
$ make
$ sudo mkdir -p /export/apps/provean/1.1.5
$ sudo chown aorth /export/apps/provean/1.1.5
$ make install
$ sudo chown -R root:root /export/apps/provean/1.1.5