htslib is an implementation of a unified C library for accessing common file formats, such as SAM, CRAM and VCF, used for high-throughput sequencing data, and is the core library used by samtools and bcftools

• Latest Version: 1.17
• Added: March, 2015
• Updated: March, 2025
• Link: https://github.com/samtools/htslib

See versions which are available:

$ module avail htslib

Load one version into your environment and run it:

$ module load htslib/1.17
$ tabix
$ bgzip

Notes from the sysadmin during installation:

$ cd /tmp
$ wget https://github.com/samtools/htslib/releases/download/1.17/htslib-1.17.tar.bz2
$ tar xf htslib-1.17.tar.bz2
$ cd htslib-1.17
$ ./configure --enable-plugins --enable-libcurl --prefix=/export/apps/htslib/1.17
$ make
$ sudo mkdir -p /export/apps/htslib/1.17
$ sudo chown aorth /export/apps/htslib/1.17
$ make install
$ sudo chown -R root:root /export/apps/htslib/1.17

Note: as of 1.17 this is compiled on CentOS Stream 8.