User Tools

Site Tools


polyphen-software

This is an old revision of the document!


PolyPhen-2

PolyPhen-2 (Polymorphism Phenotyping v2) is a software tool which predicts possible impact of amino acid substitutions on the structure and function of human proteins using straightforward physical and evolutionary comparative considerations.

Information

Usage

See versions of polyphen which are available:

$ module avail polyphen

Load polyphen:

$ module load polyphen

Installation

Notes from the sysadmin during installation:

$ cd /tmp
$ wget -qO- http://genetics.bwh.harvard.edu/pph2/dokuwiki/_media/polyphen-2.2.2r405c.tar.gz | tar xzv
$ cd polyphen-2.2.2/
$ scl enable devtoolset-3 bash
$ module load perl/5.22.3
$ cpanm DBD::SQLite
$ sudo mkdir -p /export/apps/polyphen/2.2.2
$ sudo chown -R joguya:joguya /export/apps/polyphen/2.2.2
$ ./configure
$ make download
$ make
$ make install
$ cp -r . /export/apps/polyphen/2.2.2
$ sudo chown -R root:root /export/apps/polyphen/2.2.2
polyphen-software.1489062516.txt.gz · Last modified: 2017/03/09 15:28 by joguya